Autophagy in Neutrophils: From Granulopoiesis to Neutrophil Extracellular Traps
نویسندگان
چکیده
منابع مشابه
Neutrophil extracellular traps
Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.
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BACKGROUND Sepsis is associated with systemic inflammatory responses and induction of coagulation system. Neutrophil extracellular traps (NETs) constitute an antimicrobial mechanism, recently implicated in thrombosis via platelet entrapment and aggregation. METHODOLOGY/PRINCIPAL FINDINGS In this study, we demonstrate for the first time the localization of thrombogenic tissue factor (TF) in NE...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2018
ISSN: 2296-634X
DOI: 10.3389/fcell.2018.00109